Role of Plant Secondary Compounds in the Cell Cycle

My involvement with the Arkansas INBRE  and RI INBRE has lead to a strong collaboration between Dr. Marie Chow at the University of Arkansas of the Medical Sciences, Dr. Steven Moss from Brown University  and myself.  Together we developed a new project that was funded by RI INBRE to study particular plant secondary metabolites in both Plant callus tissue and animal gastric cancer cells. Our preliminary data show that, in Rubus, phenolics, produced in the head structure of the glandular trichomes, are transported to cellular nuclei in the underlying stalk tissue.  Due to the nuclear localization of these phenolics and the cell proliferative response that is subsequently induced, we have hypothesized that these phenolics represent a new class of plant hormones that activate developmentally-regulated signal transduction pathways.  We further hypothesized that these phenolics also are able to activate mammalian signaling pathways by mimicking small molecule ligands.

 

References

Stafstrom, K.*, Liptak, S.*, Bierce, A.*, Guarracino, A.*, Crowther, T.*, Moss, S., Chow. M., Swanson, JD. (2013) Gallic acid and its effect on gastric cancer and Rubus callus. 5th biennial Northeast Regional IDeA Conference. Newark DE, August 14-16, 2013

Stafstrom, K.,  Bierce, A., Gallipoli, A., Guaraccino, A., Morton, K., Shea, J., Zhang, S., Moss., S., Swanson, J.D. (2013) Effect of Gallic Acid Exposure on Rubus Callus and Mammalian Stomach Cancer Cells.  Plant and Animal Genome Meeting XXI, San Diego, CA. Jan 12-16, 2013

Guarracino, A., Stafstrom, K., Bierce, A., Zhang, S., Moss, S., Swanson, JD. (2012) The Effectiveness of the Plant Polyphenol Gallic Acid on Cell Cycle Arrest in Gastric Cancer Cells. 5th Annual RI SURF Conference, University of Rhode Island, Kingston RI, July 27, 2012

Bierce, A., Guarracino, A., Stafstrom, K., Swanson, JD. (2012) Growing Raspberry Callus and Studying the Effect of Gallic Acid. 5th Annual RI SURF Conference, University of Rhode Island, Kingston RI, July 27, 2012

Stafstrom, K., Guarracino, A., Bierce, A., Swanson, JD. (2012) Investigation of Human Cyclin-Dependent Kinases and Their Expression Post-Exposure to Gallic Acid.  5th Annual RI SURF Conference, University of Rhode Island, Kingston RI, July 27, 2012

Skiver, N, Chow, M, Swanson JD (2010) Examining the Effects of Gallic Acid on Plant and Mammalian Cells Via Flow Cytometry. Arkansas INBRE Research Conference,  Oct 23-24, 2010, University of Arkansas, Fayetteville

Skiver, N., Walker, C., Gates, G., Parker, K., Swanson, J-D., (2010) The Transformation of Rubus and Its Application to the Study of Plant Secondary Metabolites in Plant and Animal Cells. HortScience 45(8):S234. (Abstr.), poster presented at the ASHS Annual Conference, Palm Desert, CA. Aug 2-5, 2010

Swanson, J-D (2009) Prickle Development of Rubus: A Model for Cell-To-Cell Communication and Cell Proliferation in Plants. Plant and Animal Genome Meeting XVII, San Diego, CA. Jan 10-14, 2009